Bulevirtide vs LL-37
Overview
Bulevirtide is primarily a antiviral peptide, while LL-37 is used for immune support.
This page compares Bulevirtide and LL-37 across their primary use, typical dosing, reported benefits and side effects, and U.S. regulatory status. For the full monograph on either compound — mechanism of action, clinical research, and references — follow the article links.
Side-by-side comparison
| Bulevirtide | LL-37 | |
|---|---|---|
| Category | Antiviral | Immune Support |
| Regulatory status (US) | FDA approved | Compounding (Rx) — Apr 2026 |
| Typical dosage | — | 2-5 mg |
| Frequency | — | twice weekly |
| Reported benefits | — | Antimicrobial activity, immune modulation, wound healing, anti-inflammatory |
| Reported side effects | — | Generally safe, minimal side effects |
Key differences
Primary use. Bulevirtide is categorised under Antiviral, while LL-37 falls under Immune Support. Their differing categories mean they are usually chosen for different goals rather than as direct substitutes.
Regulatory status. Bulevirtide: FDA-approved. LL-37: not FDA-approved; compounding permitted with a prescription as of April 2026.
Dosing. Typical dosing for Bulevirtide is not catalogued. LL-37 is typically dosed at 2-5 mg (twice weekly).
Can you stack them?
Some protocols combine peptides, but stacking Bulevirtide and LL-37 has not been validated for safety or efficacy in controlled trials. Combining compounds can change their effects and risks. Nothing here is medical advice — consult a qualified healthcare provider before starting or combining any protocol.
Frequently asked questions
- What is the difference between Bulevirtide and LL-37?
- Bulevirtide is primarily a antiviral peptide, while LL-37 is used for immune support. Bulevirtide is FDA-approved for one or more indications, whereas LL-37 is not FDA-approved; compounding permitted with a prescription (as of April 2026).
- What is Bulevirtide used for?
- First/only FDA-approved treatment for chronic hepatitis delta virus (HDV). FDA accelerated approval May 22, 2026. Brand: Hepcludex (Gilead).
- What is LL-37 used for?
- Antimicrobial defense peptide.
- Can you take Bulevirtide and LL-37 together?
- Some users combine peptides within a single protocol, but stacking Bulevirtide and LL-37 has not been established as safe or effective in controlled trials. Neither this comparison nor PeptideSciences101 is medical advice — consult a qualified healthcare provider before combining any compounds.
- Is Bulevirtide or LL-37 FDA-approved?
- Bulevirtide is FDA-approved for one or more indications. LL-37 is not FDA-approved; compounding permitted with a prescription (as of April 2026).
Read the full articles
- Bulevirtide — full monograph: mechanism, research, dosing & references
- LL-37 — full monograph: mechanism, research, dosing & references