Epitalon vs TB-500
Overview
Epitalon is primarily a anti-aging & longevity peptide, while TB-500 is used for healing & recovery.
This page compares Epitalon and TB-500 across their primary use, typical dosing, reported benefits and side effects, and U.S. regulatory status. For the full monograph on either compound — mechanism of action, clinical research, and references — follow the article links.
Side-by-side comparison
| Epitalon | TB-500 | |
|---|---|---|
| Category | Anti-aging & Longevity | Healing & Recovery |
| Regulatory status (US) | Compounding (Rx) — Apr 2026 | Compounding (Rx) — Apr 2026 |
| Typical dosage | 5-10 mg | 2-5 mg |
| Frequency | cycle | weekly |
| Reported benefits | Areas studied (research-reported, not established efficacy): telomerase activation and telomere elongation in human cell lines (PMID 12937682; DOI 10.1007/s10522-025-10315-x); increased melatonin synthesis and circadian effects in a small human study; lower overall and cardiovascular mortality in a 12-15 year single-lab trial that used pineal extract (epithalamin), not synthetic AEDG (PMID 17426848, 22451889). No independent multi-center RCTs; not FDA-approved. | Tissue repair, improved flexibility, reduced inflammation, enhanced recovery, hair growth stimulation |
| Reported side effects | Khavinson-group trials reported no serious adverse events (e.g., n=162 retinitis pigmentosa trial, PMID 12195242), but these are the only controlled safety data and remain unreplicated. Community use reports mild injection-site reactions. Theoretical concern: telomerase activation is a hallmark of most cancers, and a 2025 review (PMC11943447) notes carcinogenic potential is unstudied. No human pharmacokinetic or drug-interaction data. | Minimal side effects. Rare: headache, nausea, injection site reactions |
Key differences
Primary use. Epitalon is categorised under Anti-aging & Longevity, while TB-500 falls under Healing & Recovery. Their differing categories mean they are usually chosen for different goals rather than as direct substitutes.
Regulatory status. Epitalon: not FDA-approved; compounding permitted with a prescription as of April 2026. TB-500: not FDA-approved; compounding permitted with a prescription as of April 2026.
Dosing. Epitalon is typically dosed at 5-10 mg (cycle). TB-500 is typically dosed at 2-5 mg (weekly).
Can you stack them?
Some protocols combine peptides, but stacking Epitalon and TB-500 has not been validated for safety or efficacy in controlled trials. Combining compounds can change their effects and risks. Nothing here is medical advice — consult a qualified healthcare provider before starting or combining any protocol.
Frequently asked questions
- What is the difference between Epitalon and TB-500?
- Epitalon is primarily a anti-aging & longevity peptide, while TB-500 is used for healing & recovery. Epitalon is not FDA-approved; compounding permitted with a prescription (as of April 2026), whereas TB-500 is not FDA-approved; compounding permitted with a prescription (as of April 2026).
- What is Epitalon used for?
- Longevity, telomere support.
- What is TB-500 used for?
- Tissue repair, flexibility, inflammation.
- Can you take Epitalon and TB-500 together?
- Some users combine peptides within a single protocol, but stacking Epitalon and TB-500 has not been established as safe or effective in controlled trials. Neither this comparison nor PeptideSciences101 is medical advice — consult a qualified healthcare provider before combining any compounds.
- Is Epitalon or TB-500 FDA-approved?
- Epitalon is not FDA-approved; compounding permitted with a prescription (as of April 2026). TB-500 is not FDA-approved; compounding permitted with a prescription (as of April 2026).