AMP-K vs LL-37
Overview
AMP-K is primarily a immune support peptide, while LL-37 is used for pain management.
This page compares AMP-K and LL-37 across their primary use, typical dosing, reported benefits and side effects, and U.S. regulatory status. For the full monograph on either compound — mechanism of action, clinical research, and references — follow the article links.
Side-by-side comparison
| AMP-K | LL-37 | |
|---|---|---|
| Category | Immune Support | Pain Management |
| Regulatory status (US) | Research use only | Compounding (Rx) — Apr 2026 |
| Typical dosage | 100-200 mg | 2-5 mg |
| Frequency | daily | twice weekly |
| Reported benefits | Metabolic support, immune enhancement, cellular energy | Inflammation-related pain relief, infection-related pain support |
| Reported side effects | Generally safe | Generally safe |
Key differences
Primary use. AMP-K is categorised under Immune Support, while LL-37 falls under Pain Management. Their differing categories mean they are usually chosen for different goals rather than as direct substitutes.
Regulatory status. AMP-K: not FDA-approved; treated as a research compound. LL-37: not FDA-approved; compounding permitted with a prescription as of April 2026.
Dosing. AMP-K is typically dosed at 100-200 mg (daily). LL-37 is typically dosed at 2-5 mg (twice weekly).
Can you stack them?
Some protocols combine peptides, but stacking AMP-K and LL-37 has not been validated for safety or efficacy in controlled trials. Combining compounds can change their effects and risks. Nothing here is medical advice — consult a qualified healthcare provider before starting or combining any protocol.
Frequently asked questions
- What is the difference between AMP-K and LL-37?
- AMP-K is primarily a immune support peptide, while LL-37 is used for pain management. AMP-K is not FDA-approved; generally classified as a research compound, whereas LL-37 is not FDA-approved; compounding permitted with a prescription (as of April 2026).
- What is AMP-K used for?
- Metabolic immune support.
- What is LL-37 used for?
- Inflammatory pain modulation.
- Can you take AMP-K and LL-37 together?
- Some users combine peptides within a single protocol, but stacking AMP-K and LL-37 has not been established as safe or effective in controlled trials. Neither this comparison nor PeptideSciences101 is medical advice — consult a qualified healthcare provider before combining any compounds.
- Is AMP-K or LL-37 FDA-approved?
- AMP-K is not FDA-approved; generally classified as a research compound. LL-37 is not FDA-approved; compounding permitted with a prescription (as of April 2026).